2023 Department of Pediatrics Academic Annual Report

Purnima Singh, Ph.D., MPH, works closely with Dr. Bhatia in understanding the molecular pathogenesis of treatment-related complications in cancer survivors. Aman Wadhwa, M.D., is funded by the St. Baldrick’s Foundation, Children’s Cancer Research Fund, American Cancer Society and the American Society of Transplantation/ Cellular Therapy to determine the association between body composition and subsequent toxicities in children with cancer. He has also developed an interest in determining the role of social determinants of health in cancer outcomes. Julie Wolfson, M.D., MSHS, conducts research focused on outcome disparities among adolescents and young adults (AYAs) with cancer, and is a member of ICOS. Using funding from an NIH R01 grant, she is evaluating factors associated with inferior outcomes in AYAs with ALL through a multi-site consortium. She is national study chair of COG ACCL16N1CD, Documentation of Guideline Consistent Treatment in Adolescent and Young Adult Acute Lymphoblastic Leukemia. She has published on the impact of treatment site on differences in outcome according to age in more than 16,000 AYAs with various types of cancer. Dr. Wolfson has collaborated with investigators across pediatric and adult cancer trials consortium to help meet the unique needs of the AYA cancer population. She is co-chair (and COG champion) of a health outcomes study embedded in the NCTN AYA ALL study (A041501-HO). Her collaborations have also led to successful development of a local AYA program. She serves as director of the UAB AYA Oncology and Oncofertility Program. 2023 PUBLICATIONS HIGH-IMPACT PUBLICATIONS Blood Adv. 2023 Jul 10;bloodadvances.2023010101. Natural History and Variability in Albuminuria in Pediatric and Murine Sickle Cell Anemia . Malgorzata Kasztan, Inmaculada Aban, Kayla Baker, Michael Ho, Chibuzo Ilonze, Jeffrey Lebensburger. Blood. 2023 Apr 17;blood.2023019631. Poverty and Relapse Risk in Children with Acute Lymphoblastic Leukemia: Children’s Oncology Group Study AALL03N1 Report. Aman Wadhwa, Yanjun Chen, Lindsey Hageman, Anna Hoppmann, Anne Angiolillo, David Dickens, Joseph P Neglia, Yaddanapudi Ravindranath, Kim Ritchey, Amanda Termuhlen, F Lennie Wong, Wendy Landier, Smita Bhatia. Cancer. 2023 Jul 11. Assessment of longitudinal changes in body composition of children with lymphoma and rhabdomyosarcoma. Aman Wadhwa, Shawn Lim, Chen Dai, Gabriel Daniels, Kandice Adams, Joshua S Richman, Andrew McDonald, Grant R Williams, Smita Bhatia. Eur J Haematol. 2023 Oct 5. Adaptive functioning and academic achievement in pediatric survivors of acute lymphoblastic leukemia: Associations with executive functioning, socioeconomic status, and academic support. Victoria C Seghatol-Eslami, Edwin W Cookrd, Noha Sharafeldin, Julie Wolfson, Donna L Murdaugh. J Clin Oncol. 2023 Apr 1;41(10):1921-1932. Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study. Craig Erker, Martin Mynarek, Simon Bailey, Claire M Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M Cappellano, Vijay Ramaswamy, Alvaro Lassaletta, Sébastien Perreault, Cassie N Kline, Revathi Rajagopal, George Michaiel, Michal Zapotocky, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Eric S Sandler, Lindsey M Hoffman, Darren Klawinski, Sara Khan, Ralph Salloum, Anna L Hoppmann, Valérie Larouche, Kathleen Dorris, Helen Toledano, Stephen W Gilheeney, Mohamed S Abdelbaki, Beverly Wilson, Derek S Tsang, Jeffrey Knipstein, Michal Yalon Oren, Shafqat Shah, Jeffrey C Murray, Kevin F Ginn, Zhihong J Wang, Gudrun Fleischhack, Denise Obrecht, Svenja Tonn, Virginia L Harrod, Kara Matheson, Bruce Crooks, Douglas R Strother, Kenneth J Cohen, Jordan R Hansford, Sabine Mueller, Ashley Margol, Amar Gajjar, Girish Dhall, Jonathan L Finlay, Paul A Northcott, Stefan Rutkowski, Steven C Clifford, Giles Robinson, Eric Bouffet, Lucie Lafay-Cousin. J Clin Oncol. 2023 Nov 8:JCO2301027. Access to Care for Adolescent and Young Adults With Cancer in the United States: State of the Literature. Anne C Kirchhoff, Austin R Waters, Amy Chevrier, Julie A Wolfson. J Natl Compr Canc Netw. 2023 Aug;21(8):881-888. Understanding Causes of Inferior Outcomes in Adolescents and Young Adults With Cancer. Julie A Wolfson, Kelly M Kenzik, Blake Foxworthy, John M Salsman, Katherine Donahue, Marie Nelson, Mary Beth Littrell, Grant R Williams, Jennifer M Levine. J Pediatr Surg. 2023 Feb 17;S0022-3468(23)00138-0. Inhibition of PIM Kinases Promotes Neuroblastoma Cell Differentiation to a Neuronal Phenotype. Janet R Julson, Colin H Quinn, Laura V Bownes, Sara C Hutchins, Jerry E Stewart, Jamie Aye, Karina J Yoon, Elizabeth A Beierle. JAMA Oncol. 2023 May 11;e230525. Clinical Features and Risk Factors Associated With Multisystem Inflammatory Syndrome in Children With Cancer and COVID-19. Samantha D Martin, Elizabeth S Davis, Chen Dai, Lauren H Boal, Brook Araya, Julienne Brackett, David Dickens, Alissa Kahn, Isaac Martinez, Archana Sharma, Carla Schwalm, Paibel Aguayo-Hiraldo, Smita Bhatia, Jennifer M Levine, Emily E Johnston, Julie A Wolfson; Pediatric Oncology COVID-19 Case Consortium. JAMA. 2023 Sep 26;330(12):1175-1186. Clinical Care for People Who Survive Childhood Cancer: A Review. Smita Bhatia, Emily S Tonorezos, Wendy Landier . Lancet Child Adolesc Health. 2023 Nov;7(11):797-808. The evolving treatment landscape for children with sickle cell disease. Seethal A Jacob, Ravi Talati, Julie Kanter. Nat Commun. 2023 Feb 10;14(1):735. FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells. Qingnan Zhao, Jiemiao Hu, Lingyuan Kong, Shan Jiang, Xiangjun Tian, Jing Wang, Rintaro Hashizume, Zhiliang Jia, Natalie Wall Fowlkes, Jun Yan, Xueqing Xia, Sofia F Yi, Long Hoang Dao, David Masopust, Amy B Heimberger, Shulin Li.

2023 Academic Annual Report

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